Buy generic Cymbalta | duloxetine | Generalized anxiety disorder

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Generic Name :Generic Cymbalta Brand Name : Duloxetine
Strength(s) : 30mg / 60mg Expiry : 2019
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Cymbalta is a prescriptive drug offered for high depression and generalized anxiety disorders also known as GAD. The drug is a commercial name given to the actual drug name Duloxetine which is a serotonin-nor epinephrine reuptake inhibitor also known as SNRI. The product is manufactured and marketed by the global pharmaceutical company Eli Lilly. Cymbalta has been acceded to be prescribed for pains due to osteoarthritis and skeletal muscles.

Cymbalta was first created by a team well known pharmaceutical researchers under Eli Lilly in 1986. The patent to the drug was initially admitted in the year 1990. However, there have been quite lot of controversies to the use of Cymbalta for the prescriptions provided. Duloxetine had initially been given a dosage of 20 mg/day to the patients who did not show the required results. Later the dosage was increased to a maximum 120 mg/day which led to the increase in the liver toxicity and also increase in high blood pressures. This resulted in the irregularities in the QT interval prolongations which is the monitoring of the blood ventricles of the heart in the body. Later it was found that the use of Duloxetine hydrochloride in the presence of ethanol resulted in the drastic increase in the effect of ethanol on the liver. This showed that the QT intervals were not affected by the drug. And it was finally approved by the Food and Drug Administration (FDA) in the year 2007 for generalized anxiety disorder.

The generic Cymbalta has taken up the place as a top selling prescriptive drug in the USA and around the world today. Eli Lilly has been highly benefitted by the sales of Cymbalta. The company is looking forward for further increase in the sales of the drug in the upcoming years.

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Benefits of Using Generic Cymbalta

The primary benefit of Cymbalta is to reduce the anxiety and depression in the body. The drug is capable of providing relief from stress and depression caused due to major depressive disorders. Nowadays people buy Cymbalta online to have quick relief when in times of depressions. Sometimes the drug is bought and consumed without proper medications and prescriptions which might cause severe side effects. Otherwise, the drug is well suited in times of depressions.

duloxetine is capable of treating Fibromyalgia a chronic condition which causes pain and weakness in the body. FDA approved Cymbalta as a drug which can be used for the treatment of this condition. With direct reactions on the nerve cells of the brain the duloxetine has been treated as the most recommended drug for the treatment of Fibromyalgia.

Action Mechanism Of Generic Cymbalta

Though Duloxetine has been considered to be used for depression and anxiety disorders yet the exact mechanism of the drug on human is yet to be confirmed. Duloxetine shows an average half life of about 12 hours. The doses of Duloxetine are proportional to the therapeutic range when its pharmacokinetics is considered. After a dosing of up to 3 days, the concentrations of the plasma reach a steady state. The drug can be eliminated through the hepatic metabolism which involves 2 P450 isozymes which are known as CYP1A2 and CYP2D6.

Duloxetine hydrochloride consists of about 3% of the total labeled material present in the plasma. The pathways of the majority of biological transformations of the drug comprise of Naphthyl ring followed by conjugation and then more oxidation. The isozymes CYP1A2 and CYP2D6 help in the catalysis of the oxidation of the Naphthyl ring in the body. The metabolites present in the plasma of the body contains 4-hydroxy duloxetine glucoronide and 5-hydroxy, 6-methoxy duloxetine sulfate. Cymbalta goes under immeasurable metabolism processes that result in 70% elimination through the urine and about 20% through the feces. The drug is bonded to up to 90% of the proteins present in the plasma of the human body. It primarily bounds itself to Albumin and a 1- acid glycoprotein. Though there is still full evaluation to be done on the bounding functions of duloxetine and protein drugs, yet the results for the binding of plasma protein to duloxetine has been evaluated which shows that is does not get affected by renal or hepatic impairments. After the inhaling of the drug its absorption takes about 2 hours to initiate. The maximum concentration after the absorption takes place 6 hours after the dosage of Cymbalta. However, the consumption of food after the medication results in delay in the time of the process to begin. The decrease in the rate is taken up to 10 %.

Precautions before Using Generic Cymbalta

Patients who have high depressive disorders may experience the increase in the depression and anxiety. Without proper prescription of generic Cymbalta, the patients may experience depressing and suicidal thoughts. The behavior of the patients also experience unusual changes in it. If a patient is already experiencing such suicidal thoughts and changes then he might face worsened conditions in the behavior after the taking of the drug. People usually buy Cymbalta due to it being an anti depression drug but without proper prescription and dosage the drug might enhance the conditions in the patients resulting in increase in the suicidal thoughts and depression. Cymbalta should therefore be taken after proper consultation of a qualified doctor.

The patients need to be monitored exclusively and need to be observed closely for any indication in clinical worsened situations, thoughts of suicide, and unusual changes in behavior, predominantly during the first months of the prescribed therapy session. The drug prescription also needs to be monitored during the increase or decrease in the dosage of the drug in the patients. There are a various symptoms which have been recorded in the patients who have been treated for the generalized anxiety disorder from time to time. Some of these symptoms are panic attacks, irritability, agitation, anxiety, insomnia, aggressiveness, restlessness, impulsive nature and hypomania. Though there is not a proper analysis but still these symptoms are taken as initiation of suicidal conditions in the patients. If such symptoms are faced then precautions need to be taken up before taking up further doses of the drug.

Possible side effects Of Generic Cymbalta

There are few side effects due to the drug if not taken under proper prescriptive measures. Most of these side effects are general and are considered common during the doses of the drug. The doses of Cymbalta can result in increased sweating among the patients. duloxetine is also capable of causing sleepiness and insomniac conditions at times. The appetite of the patient can also be affected by the medication of the drug. Without proper food to consume the patient might experience constipation during the medication of the drug. Cymbalta can also cause dry mouth conditions which make it a little uncomfortable. Weakness and dizziness due to the medication can also be experienced.

Dosage and Administration Of Generic Cymbalta

Cymbalta needs to be taken up according to the various disorders related to anxiety and depression. For major depressive disorder (MDD) a total dose of 40 mg/day to 60 mg/day needs to be taken. For some patients less doses are given in the starting which are increased after a little habit of the medicine. A dose of above 120mg/ day is strictly prohibited. For generalized anxiety disorder a dose of 60mg/day is given at a time for a week. And similar prescriptions as MDD are followed after that. For Fibromyalgia also the prescription is 60mg/day for a week daily.


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